nirogacestat hydrobromide

{
  "id": "MLC-T-ONC-005845",
  "term": "nirogacestat hydrobromide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat adults with desmoid tumors (a type of soft tissue tumor) that have gotten worse and need systemic therapy. It is also being studied in the treatment of other types of cancer. Nirogacestat hydrobromide binds to a protein called gamma secretase, which blocks the activation of other proteins called Notch receptors. Blocking these proteins may help keep tumor cells from growing and may kill them. Nirogacestat hydrobromide is a type of gamma secretase inhibitor. Also called Ogsiveo.",
    "The hydrobromide salt form of nirogacestat, a selective gamma secretase (GS) inhibitor with antitumor activity. Upon administration, nirogacestat targets and binds to GS, thereby blocking the proteolytic activation of Notch receptors. This inhibits the Notch signaling pathway and results in the induction of apoptosis in tumor cells that overexpress Notch. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth and survival."
  ],
  "synonyms": [
    "Ogsiveo"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nirogacestat-hydrobromide/"
}