Allogeneic DNT cells RC1012

{
  "id": "MLC-T-ONC-009879",
  "term": "Allogeneic DNT cells RC1012",
  "field": "Oncology and biomedicine",
  "definition": "A population of off-the-shelf (OTS) healthy, donor-derived CD4 and CD8 double-negative T lymphocytes (allo-DNTs), with potential immunomodulating and anti-leukemic activities. The DNTs are expanded ex vivo in order to enhance their tumor destroying potential. Upon administration of the allo-DNTs RC1012, the receptor type II integral membrane protein (KLRK1; NKG2D) and DNAX accessory molecule 1 (cluster of differentiation 226; CD226; DNAM-1) expressed on the DNTs recognize and bind to their cognate ligands expressed on leukemia cells. Upon binding, the DNTs release interferon-gamma (IFN-g), thereby destroying the tumor cells. NKG2D, a member of the CD94/NKG2 family of C-type lectin-like receptors, and DNAM-1, a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set, play a key role in natural killer cell (NK)-mediated tumor cell killing. Certain tumor cells express higher levels of NKG2D and DNAM-1 ligands on their surfaces, thereby increasing their susceptibility to DNT-mediated cell lysis.",
  "synonyms": [
    "Allo-DNT cells RC1012",
    "Allo-DNTs RC1012",
    "allogeneic DNTs RC1012",
    "allogeneic double-negative T cells RC1012",
    "bi-negative T cells RC1012",
    "CD3+CD4-CD8-T cells RC1012"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-dnt-cells-rc1012/"
}