allogeneic NKG2D CAR memory T cells

{
  "id": "MLC-T-ONC-009933",
  "term": "allogeneic NKG2D CAR memory T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of donor-derived memory T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) encoding human natural-killer group 2, member D receptor protein (NKG2D or KLRK1), with potential antineoplastic activity. Upon administration, the allogeneic NKG2D CAR memory T cells specifically recognize and bind to tumor cells expressing NKG2D ligands (NKG2DLs), resulting in cytokine secretion and lysis of NKG2D ligand-expressing tumor cells. NKG2DLs, such as MICA, MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on a variety of cancer cell types, but are not expressed on most normal, healthy cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-nkg2d-car-memory-t-cells/"
}