autologous anti-NKG2DLs CAR-T cells LEU011

{
  "id": "MLC-T-ONC-011485",
  "term": "autologous anti-NKG2DLs CAR-T cells LEU011",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting natural-killer group 2, member D ligands (NKG2DLs), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-NKG2DLs CAR-T cells LEU011 specifically recognize and induce selective toxicity in tumor cells expressing NKG2DLs. Ligands for NKG2D, such as MHC class I chain-related protein A (MICA), MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on various cancer cell types, but are not expressed on most normal, healthy cells.",
  "synonyms": [
    "autologous anti-NKG2DL CAR T cells LEU 011",
    "autologous NKG2D ligands-targeting CAR T cells LEU011",
    "autologous NKG2DLs-targeting CAR T cells LEU011"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-nkg2dls-car-t-cells-leu011/"
}