MLchartDataset catalogue

alvespimycin hydrochloride

Term · Oncology and biomedicine · MLC-T-ONC-010010

The hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.

Table 1. Record
IdentifierMLC-T-ONC-010010
FieldOncology and biomedicine
Abbreviation17-DMAG HCL
ReferencesNational Cancer Institute Thesaurus (CC BY 4.0)
Record as JSON 
{
  "id": "MLC-T-ONC-010010",
  "term": "alvespimycin hydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.",
  "abbreviation": "17-DMAG HCL",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/alvespimycin-hydrochloride/"
}

Record 929 of 17,721 in Oncology and biomedicine terminology (MLC-0111). Request the full dataset.