alvocidib hydrochloride

{
  "id": "MLC-T-ONC-010012",
  "term": "alvocidib hydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The hydrochloride salt form of alvocidib, a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.",
  "abbreviation": "FLAVO",
  "synonyms": [
    "flavopiridol",
    "flavopiridol hydrochloride"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/alvocidib-hydrochloride/"
}