CDK inhibitor P276-00

{
  "id": "MLC-T-ONC-012436",
  "term": "CDK inhibitor P276-00",
  "field": "Oncology and biomedicine",
  "definition": "A flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. P276-00 selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.",
  "synonyms": [
    "cyclin-dependent kinase inhibitor P276"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cdk-inhibitor-p276-00/"
}