anti-AG7 antibody drug conjugate AbGn-107

{
  "id": "MLC-T-ONC-010115",
  "term": "anti-AG7 antibody drug conjugate AbGn-107",
  "field": "Oncology and biomedicine",
  "definition": "An antibody drug conjugate (ADC) composed of a monoclonal antibody that targets the tumor-associated antigen (TAA) AG7 and is linked, through a hydrophilic, self-immolative linker, to a proprietary cytotoxic payload, with potential antineoplastic activity. Upon administration of AbGn-107 the antibody moiety targets and binds to the AG7 antigen expressed on a variety of cancer cells. Upon binding and internalization, the linker is cleaved and the payload is released, binds to tubulin, inhibits tubulin polymerization and kills the AG7-expressing tumor cells.",
  "synonyms": [
    "ADC AbGn-107",
    "Ab1-18Hr1",
    "anti-AG7 ADC AbGn-107",
    "AbGn107"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ag7-antibody-drug-conjugate-abgn-107/"
}