anti-AGS-16 monoclonal antibody AGS-16M18

{
  "id": "MLC-T-ONC-010116",
  "term": "anti-AGS-16 monoclonal antibody AGS-16M18",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against the activator of g-proteins signaling (AGS) cell surface protein AGS-16 with potential antineoplastic activity. Anti-AGS-16 monoclonal antibody AGS-16M18 selectively binds to AGS-16, triggering complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) in tumor cells expressing AGS-16. While normally expressed at low levels in the proximal tubules of the kidney, AGS-16 has been found to be overexpressed in more than 95% of kidney and 40% of liver neoplasms.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ags-16-monoclonal-antibody-ags-16m18/"
}