anti-AGS-8 monoclonal antibody AGS-8M4

{
  "id": "MLC-T-ONC-010118",
  "term": "anti-AGS-8 monoclonal antibody AGS-8M4",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against the activator of g-proteins signaling (AGS) cell surface protein AGS-8 with potential antineoplastic activity. Anti-AGS-8 monoclonal antibody AGS-8M4 selectively binds to AGS-8, triggering complement-dependent cell lysis and antibody-dependent cell-mediated cytotoxicity in tumor cells expressing AGS-8. While normally expressed at low levels in the heart in response to ischemia, AGS-8 has been found to be expressed in more than 70% of ovarian neoplasms.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ags-8-monoclonal-antibody-ags-8m4/"
}