anti-B7H7 monoclonal antibody HBM1020

{
  "id": "MLC-T-ONC-010155",
  "term": "anti-B7H7 monoclonal antibody HBM1020",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant human monoclonal antibody directed against HERV-H LTR-associating protein 2 (HHLA2; B7 homolog 7; B7H7), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-B7H7 monoclonal antibody HBM1020 binds to B7H7 and blocks the interaction between B7H7 and its receptors. This abrogates the B7H7-mediated inhibition of T-cell and nature killer (NK) cell activation, which may lead to enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response and NK cell cytotoxicity against cancer cells. B7H7, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and a negative regulator of T-cell and NK-cell activation.",
  "synonyms": [
    "anti-HHLA2 monoclonal antibody HBM1020"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-b7h7-monoclonal-antibody-hbm1020/"
}