anti-HHLA2 monoclonal antibody NPX887

{
  "id": "MLC-T-ONC-010784",
  "term": "anti-HHLA2 monoclonal antibody NPX887",
  "field": "Oncology and biomedicine",
  "definition": "A human immunoglobulin G1 (IgG1) monoclonal antibody directed against HERV-H LTR-associating protein 2 (HHLA2; HHLA-2; B7 homolog 7; B7-H7), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-HHLA2 monoclonal antibody NPX887 targets and binds to HHLA2, and blocks the interaction between HHLA2 and its receptors. This abrogates the HHLA2-mediated inhibition of T-cell and nature killer (NK) cell activation, which may lead to enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response and NK cell cytotoxicity against cancer cells. HHLA2, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and a negative regulator of T-cell and NK cell activation.",
  "synonyms": [
    "anti-B7-H7 monoclonal antibody NPX887",
    "anti-HHLA-2 monoclonal antibody NPX887"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-hhla2-monoclonal-antibody-npx887/"
}