anti-HGF monoclonal antibody YYB101

{
  "id": "MLC-T-ONC-010783",
  "term": "anti-HGF monoclonal antibody YYB101",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against human hepatocyte growth factor (HGF), with potential antineoplastic activity. Upon administration, anti-HGF monoclonal antibody YYB101 targets and binds to HGF, preventing the binding of HGF to the HGF receptor c-Met and the activation of the c-Met signaling pathway. This may result in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.",
  "synonyms": [
    "anti-hepatocyte growth factor monoclonal antibody YYB101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-hgf-monoclonal-antibody-yyb101/"
}