ficlatuzumab

{
  "id": "MLC-T-ONC-013598",
  "term": "ficlatuzumab",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody directed against human hepatocyte growth factor (HGF) with potential antineoplastic activity. Ficlatuzumab binds to the soluble ligand HGF, preventing the binding of HGF to its receptor c-Met and activation of the HGF/c-Met signaling pathway, which may result in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.",
  "synonyms": [
    "anti-HGF monoclonal antibody SCH900105"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ficlatuzumab/"
}