anti-HGF monoclonal antibody TAK-701

{
  "id": "MLC-T-ONC-010782",
  "term": "anti-HGF monoclonal antibody TAK-701",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against human hepatocyte growth factor (HGF) with potential antineoplastic activity. Anti-HGF monoclonal antibody TAK-701 binds to the soluble ligand HGF, preventing HGF binding to and activation of the HGF receptor c-Met and so the activation of the c-Met signaling pathway; this may result in the induction of cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in a variety of tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.",
  "synonyms": [
    "anti-hepatocyte growth factor monoclonal antibody TAK-701",
    "anti-HGF MoAb TAK-701"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-hgf-monoclonal-antibody-tak-701/"
}