anti-HIF-1alpha LNA antisense oligonucleotide EZN-2968

{
  "id": "MLC-T-ONC-010785",
  "term": "anti-HIF-1alpha LNA antisense oligonucleotide EZN-2968",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic antisense oligodeoxynucleotide (AS ODN) targeting hypoxia-inducible factor-1alpha (HIF-1alpha) with potential antineoplastic activity. Anti-HIF-1alpha LNA antisense oligonucleotide EZN-2968 hybridizes with HIF-1alpha mRNA and blocks t HIF-1 alpha protein expression, which may result in the inhibition of angiogenesis, the inhibition of tumor cell proliferation, and apoptosis. HIF-1alpha, normally activated in response to hypoxia-induced stress, is a key transcription regulator of a large number of genes important in cellular adaptation to low-oxygen conditions, including angiogenesis, cell proliferation, apoptosis, and cell invasion.",
  "synonyms": [
    "anti-HIF-1alpha LNA AS-ODN"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-hif-1alpha-lna-antisense-oligonucleotide-ezn-2968/"
}