Androgen Receptor Antisense Oligonucleotide EZN-4176

{
  "id": "MLC-T-ONC-010071",
  "term": "Androgen Receptor Antisense Oligonucleotide EZN-4176",
  "field": "Oncology and biomedicine",
  "definition": "A locked nucleic acid (LNA)-based antisense oligonucleotide targeting the androgen receptor (AR) mRNA, with potential antineoplastic activity. Upon administration, EZN-4176 is hybridized and releases the complementary sequences of AR mRNA, thereby blocking translation of the AR protein and inhibiting AR-induced tumor cell growth and promoting tumor cell apoptosis in AR-overexpressing tumor cells. AR is overexpressed in certain breast and prostate cancers and is involved in tumor cell proliferation and survival. LNAs contain a methylene bridge linking 2'-oxygen and 4'-carbon of ribose sugar rings, thereby increasing their thermal stability and decreasing degradation.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/androgen-receptor-antisense-oligonucleotide-ezn-4176/"
}