miR-221 LNA inhibitor LNA-i-miR-221

{
  "id": "MLC-T-ONC-015194",
  "term": "miR-221 LNA inhibitor LNA-i-miR-221",
  "field": "Oncology and biomedicine",
  "definition": "A phosphorothioate (PS) modified backbone 13-mer locked nucleic acid (LNA)-based antisense oligonucleotide (ASO) and inhibitor of the oncogenic microRNA (miRNA) miR-221, with potential chemo-sensitizing and antineoplastic activities. Upon administration, miR-221 LNA inhibitor LNA-i-miR-221 hybridizes with endogenous miR-221 and inhibits miR-221-mediated functions involving tumor cell proliferation, angiogenesis and metastasis, and the modulation of drug influx-efflux transporters as it regulates the expression of a variety of target genes. miR-221, oncogenic miRNA that is upregulated in various malignancies, plays important roles in tumor cell proliferation, angiogenesis and metastasis, and in the development of drug resistance such as melphalan resistance.",
  "synonyms": [
    "LNA-i-miR-221",
    "miR-221 locked nucleic acid-based antisense oligonucleotide LNA-i-miR-221",
    "miR-221 LNA ASO LNA-i-miR-221"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mir-221-lna-inhibitor-lna-i-mir-221/"
}