anti-BTN3A agonistic monoclonal antibody ICT01

{
  "id": "MLC-T-ONC-010188",
  "term": "anti-BTN3A agonistic monoclonal antibody ICT01",
  "field": "Oncology and biomedicine",
  "definition": "A humanized agonistic monoclonal antibody directed against butyrophilin subfamily 3 member A (BTN3A; CD277), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-BTN3A agonistic monoclonal antibody ICT01 targets and binds to BTN3A present on epithelial and tumor cells. BTN3A binding may sensitize tumor cells to gamma 9 delta 2 (Vg9Vd2) T-cell killing. The Vg9Vd2 T cells secrete effector cytokines and exert a cytolytic effect on tumor cells. This may abrogate BTN3A-mediated tumor immunity and may enhance anti-tumor immune response. BTN3A, a member of the butyrophilin superfamily of immunomodulators, is upregulated in tumor cells.",
  "synonyms": [
    "anti-BTN3A agonist monoclonal antibody ICT01"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-btn3a-agonistic-monoclonal-antibody-ict01/"
}