anti-CDH6/exatecan ADC CUSP06

{
  "id": "MLC-T-ONC-010456",
  "term": "anti-CDH6/exatecan ADC CUSP06",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed against the tumor-associated antigen (TAA) cadherin-6 (CDH6; CDH-6; K-cadherin) conjugated, via a protease cleavable linker, to the camptothecin analog and cytotoxic DNA topoisomerase I inhibitor exatecan, with potential antineoplastic activity. Upon administration of anti-CDH6/exatecan ADC CUSP06, the anti-CDH6 antibody moiety targets and binds to CDH6-expressing tumor cells. Upon uptake and cleavage of the linker by proteases, exatecan targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication and induction of apoptosis. This inhibits the proliferation of CDH6-expressing tumor cells. In addition, this may cause a bystander effect, thereby further killing CDH6-expressing tumor cells. CDH6, a member of the cadherin family and overexpressed by a variety of cancers, plays a key role in tumor cell proliferation.",
  "synonyms": [
    "anti-cadherin-6 ADC CUSP06",
    "anti-CDH6 ADC CUSP06",
    "CDH6-targeting antibody-drug conjugate CUSP06"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cdh6-exatecan-adc-cusp06/"
}