anti-CTLA4 antibody Fc fusion protein KN044

{
  "id": "MLC-T-ONC-010545",
  "term": "anti-CTLA4 antibody Fc fusion protein KN044",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant, humanized fusion protein consisting of a cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4) single domain antibody linked to a Fc domain, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CTLA4 antibody Fc fusion protein KN044 targets and binds to CTLA4 expressed on T cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system.",
  "synonyms": [
    "anti-CTLA4 antibody fusion protein KN044"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ctla4-antibody-fc-fusion-protein-kn044/"
}