anti-CTLA4 mAb RNA/GITRL RNA-transfected autologous dendritic cell vaccine

{
  "id": "MLC-T-ONC-010546",
  "term": "anti-CTLA4 mAb RNA/GITRL RNA-transfected autologous dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. Anti-CTLA4 MoAb RNA/GITRL RNA-transfected DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4) monoclonal antibody and tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T lymphocytes, while expression of GlTRL modulates T-lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses.",
  "abbreviation": "GITRL/antiCTLA4 RNA DC",
  "synonyms": [
    "anti-CTLA-4 mAb heavy and light chain RNA/GITRL RNA-transfected autologous DC"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ctla4-mab-rna-gitrl-rna-transfected-autologous-dendritic-cell-vaccine/"
}