Trimeric GITRL-Fc OMP-336B11

{
  "id": "MLC-T-ONC-017327",
  "term": "Trimeric GITRL-Fc OMP-336B11",
  "field": "Oncology and biomedicine",
  "definition": "A Fc-engineered human fusion protein composed of two trimers of tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18; GlTRL) linked to an immunoglobulin Fc domain (GITRL-Fc), with potential immunostimulatory and antineoplastic activities. Upon administration, trimeric GITRL-Fc OMP-336B11 targets, binds to and activates its co-stimulatory surface receptor (glucocorticoid-induced tumor necrosis factor receptor (GITR; TNFRSF18) expressed on T lymphocytes and certain tumor cell types. This activates T lymphocytes, causes T-lymphocyte proliferation and suppresses the activity of regulatory T cells (Treg). This promotes cytotoxic T-lymphocyte (CTL)-mediated killing of tumor cells. GITRL, a member of the tumor necrosis factor (TNF) family of ligands, functions to activate the co-stimulatory receptor GITR to enhance T-cell-modulated immune responses.",
  "synonyms": [
    "GITRL-Fc",
    "GITRL-Fc trimer"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/trimeric-gitrl-fc-omp-336b11/"
}