Anti-human GITR monoclonal antibody TRX518

{
  "id": "MLC-T-ONC-010802",
  "term": "Anti-human GITR monoclonal antibody TRX518",
  "field": "Oncology and biomedicine",
  "definition": "A humanized, Fc disabled anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) monoclonal antibody (MoAb) with immunomodulating activity. Anti-human GITR MoAb TRX518 blocks the interaction of GITR, found on multiple types of T cells, with its ligand, thereby inducing both the activation of tumor-antigen-specific T effector cells, as well as abrogating the suppression induced by inappropriately activated T-regulatory cells. This agent is shown to act synergistically with chemotherapeutic drugs in multiple cancer models.",
  "abbreviation": "anti-huGITR MoAb TRX518",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-human-gitr-monoclonal-antibody-trx518/"
}