anti-GITR agonistic monoclonal antibody MS-986156

{
  "id": "MLC-T-ONC-010702",
  "term": "anti-GITR agonistic monoclonal antibody MS-986156",
  "field": "Oncology and biomedicine",
  "definition": "An anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR; tumor necrosis factor superfamily member 18; TNFRSF18; CD357) agonistic monoclonal antibody, with potential immune checkpoint modulating activity. Anti-GITR antibody BMS-986156 binds to and activates GITR, which is expressed on the cell surface of multiple types of T cells. This stimulates the immune system, induces both the activation and proliferation of tumor antigen-specific T-effector cells (Teffs), and suppresses the function of activated T-regulatory cells (Tregs). This leads to tumor cell eradication. GITR, a member of the TNF receptor superfamily and T-cell receptor co-stimulator, is expressed on the surface of multiple immune cell types, including Tregs, Teffs, B cells, and natural killer (NK) cells. Inappropriately activated Tregs suppress both Teffs and T-cell receptor (TCR) signaling.",
  "synonyms": [
    "GITR agonist BMS-986156",
    "TNFRSF18 agonist BMS-986156",
    "anti-GITR MoAb BMS-986156"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-gitr-agonistic-monoclonal-antibody-ms-986156/"
}