GITRL RNA-transfected autologous dendritic cell vaccine

{
  "id": "MLC-T-ONC-013949",
  "term": "GITRL RNA-transfected autologous dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. GITRL RNA-transfected autologous DC vaccine is prepared by transfecting DCs with RNAs encoding tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of GlTRL results in modulating T lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses.",
  "abbreviation": "GITRL RNA DC",
  "synonyms": [
    "GITRL RNA-transfected autologous dendritic cells",
    "GITRL RNA-transfected autologous DC"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gitrl-rna-transfected-autologous-dendritic-cell-vaccine/"
}