hTERT/survivin/melanoma tumor cell-derived mRNA-transfected dendritic cell vaccine

{
  "id": "MLC-T-ONC-014228",
  "term": "hTERT/survivin/melanoma tumor cell-derived mRNA-transfected dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine containing dendritic cells (DCs) that are transfected with messenger RNA (mRNA) encoding human telomerase reverse transcriptase (hTERT) and survivin in addition to patient-specific melanoma-derived mRNA with potential immunostimulatory and antineoplastic activities. Upon administration, hTERT/survivin/melanoma tumor cell-derived mRNA-transfected dendritic cell vaccine may elicit a highly specific cytotoxic T-cell (CTL) response against melanoma cells expressing hTERT, survivin, and patient-specific melanoma-associated antigens. hTERT, the catalytic subunit of human telomerase, and survivin, a member of the inhibitor of apoptosis (IAP) family of proteins, may be upregulated in certain tumor cell types, playing key roles in tumor cell growth and survival.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/htert-survivin-melanoma-tumor-cell-derived-mrna-transfected-dendritic-cell/"
}