autologous OFA-iLRP RNA-transfected dendritic cell vaccine

{
  "id": "MLC-T-ONC-011728",
  "term": "autologous OFA-iLRP RNA-transfected dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of autologous, mature monocyte-derived dendritic cells (DCs) transfected with oncofetal antigen immature laminin receptor protein (OFA-iLRP) RNA, with potential antineoplastic activity. Upon administration, DCs in the OFA-iLRP RNA-transfected autologous dendritic cell vaccine express, process, and present OFA-iLRP to the host immune system, which may mount a potent cytotoxic T-cell (CTL) response against OFA-iLRP-expressing tumor cells. As a highly conserved protein, OFA-iLRP is preferentially expressed in fetal tissues and in many types of cancer, including hematopoietic malignancies, but is not detectable in normal differentiated adult cells.",
  "synonyms": [
    "oncofetal antigen-immature laminin receptor protein-loaded autologous dendritic cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-ofa-ilrp-rna-transfected-dendritic-cell-vaccine/"
}