autologous cytotoxic T lymphocytes induced with MUC1 gene-transfected dendritic cells

{
  "id": "MLC-T-ONC-011596",
  "term": "autologous cytotoxic T lymphocytes induced with MUC1 gene-transfected dendritic cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous cytotoxic T-lymphocytes (CTL), specifically reactive to the tumor-associated antigen (TAA) mucin-1 (MUC1), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are collected from the patient with MUC1-positive tumors and are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding MUC1 to generate MUC1-specific CTLs, which are subsequently expanded in vitro. Upon re-infusion of autologous CTLs induced with MUC1 gene-transfected DCs to the patient, the CTLs target and lyse the MUC1-expressing tumor cells. This inhibits tumor cell proliferation. MUC1 is expressed by a variety of tumor cell types.",
  "synonyms": [
    "MUC1-gene-DC-CTL",
    "MUC1-DC-CTL"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cytotoxic-t-lymphocytes-induced-with-muc1-gene-transfected-dendritic/"
}