autologous dendritic cell vaccine ACT2001

{
  "id": "MLC-T-ONC-011599",
  "term": "autologous dendritic cell vaccine ACT2001",
  "field": "Oncology and biomedicine",
  "definition": "A cell-based cancer vaccine composed of autologous, immature dendritic cells (DCs), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, immature DCs are isolated and re-administered intra-tumorally. The immature DCs internalize and process the tumor-associated antigens (TAAs), migrate to the lymphatic system, and then expose the immune system to the TAAs. This induces a specific cytotoxic T-lymphocyte (CTL) response against the cancer cells leading to tumor cell lysis.",
  "synonyms": [
    "autologous DC vaccine ACT2001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-dendritic-cell-vaccine-act2001/"
}