autologous deep IL-15 primed T cells TRQ15-01

{
  "id": "MLC-T-ONC-011598",
  "term": "autologous deep IL-15 primed T cells TRQ15-01",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of genetically modified, multi-antigen-directed autologous T lymphocytes, that have particles, consisting of multiple chemically crosslinked human cytokine interleukin-15 (IL-15)/IL-15 receptor alpha (IL-15Ra)/Fc heterodimers, attached to their surface, with potential immunostimulating and antineoplastic activities. TRQ15-01 is made from monocyte-derived dendritic cells (moDCs) that are pulsed with peptides from multiple tumor-associated antigens (TAAs) to expand cytotoxic T lymphocytes (CTLs) that are subsequently loaded with IL-15 particles. Upon administration of the autologous deep IL-15 primed T cells, the IL-15/IL-15Ra fusion proteins are slowly released in vivo from the T cells in a controlled manner and induce autocrine cytokine stimulation of the administered T cells, thereby increasing T-cell division of the administered T cells. The expanded T cells target, bind to and kill tumor cells. This increases tumor cell growth inhibition by T cells. IL-15 is a pro-survival, inflammatory cytokine and causes sustained T-cell expansion and enhanced anti-tumor activity. Compared to systemically delivered IL-15, IL-15 attached to the T cells greatly increases target CD8 T-cell concentrations in the tumor, without significant systemic effects.",
  "synonyms": [
    "IL-15 loaded autologous T lymphocytes TRQ15-01"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-deep-il-15-primed-t-cells-trq15-01/"
}