anti-FOLR1 CoStAR-expressing autologous tumor-infiltrating lymphocytes ITIL-306

{
  "id": "MLC-T-ONC-010669",
  "term": "anti-FOLR1 CoStAR-expressing autologous tumor-infiltrating lymphocytes ITIL-306",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor infiltrating lymphocytes (TILs) genetically engineered to express a co-stimulatory antigen receptor (CoStAR) specific for folate receptor alpha (FolRa; FOLR1) and linked to the co-stimulatory domains CD28 and CD40, with potential immunomodulating and antineoplastic activities. Upon administration, the anti-FOLR1 CoStAR-expressing autologous TILs ITIL-306 specifically target, bind to and kill the FOLR1-expressing tumor cells. In addition, ITIL-306, by binding to FOLR1, is able to activate the TILs through the costimulatory signals. This increases T-cell proliferation and activation in the tumor microenvironment (TME), thereby enhancing the T-cell-mediated anti-tumor immune response against the FOLR1-expressing tumor cells. FOLR1 is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues. CoStAR provides synthetic costimulation in the TME and increases T-cell proliferation and survival, and improves the effector function of T cells, which may boost the efficacy of TILs.",
  "synonyms": [
    "anti-FOLR1 CoStAR-expressing autologous TILs ITIL-306",
    "autologous CoStAR-TILs ITIL-306",
    "autologous anti-FOLR1 CoStAR-TILs ITIL-306",
    "CoStAR-modified autologous TILs ITIL-306"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-folr1-costar-expressing-autologous-tumor-infiltrating-lymphocytes-itil-306/"
}