anti-FOLR1 CAR T cells

{
  "id": "MLC-T-ONC-010668",
  "term": "anti-FOLR1 CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) specific for folate receptor alpha (FolRa; FOLR1), with potential immunostimulating and antineoplastic activities. Upon administration, anti-FOLR1 CAR T cells specifically recognize and bind to FOLR1-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. FOLR1 is a glycosylphosphatidylinositol linked cell surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues.",
  "synonyms": [
    "anti-FOLR1 CAR-T cells",
    "FH-FOLR1 CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-folr1-car-t-cells/"
}