anti-folate receptor alpha antibody-drug conjugate AMT-151

{
  "id": "MLC-T-ONC-010666",
  "term": "anti-folate receptor alpha antibody-drug conjugate AMT-151",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting folate receptor alpha (FRa; FolRa; FOLR1) conjugated to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-FRa ADC AMT-151, the antibody moiety targets and binds to FRa expressed on tumor cells. Upon cellular uptake and internalization, the cytotoxic agent inhibits tumor cell proliferation through an as of yet undisclosed mechanism of action (MoA). FRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues.",
  "synonyms": [
    "anti-folate receptor alpha ADC AMT-151",
    "anti-FRa ADC AMT-151",
    "anti-FolRa ADC AMT-151",
    "anti-FOLR1 ADC AMT-151"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-folate-receptor-alpha-antibody-drug-conjugate-amt-151/"
}