anti-FRalpha antibody-drug conjugate ZW191

{
  "id": "MLC-T-ONC-010672",
  "term": "anti-FRalpha antibody-drug conjugate ZW191",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting folate receptor alpha (FRa; FolRa; FOLR1) conjugated, via a maleimidocaproyl (MC) anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) protease-cleavable linker, to the camptothecin-based topoisomerase 1 inhibitor ZD06519, with potential antineoplastic activity. Upon administration of anti-FRalpha ADC ZW191, the antibody moiety targets and binds to FRa expressed on tumor cells. Upon binding, cellular uptake and linker cleavage, ZD06519 is released. ZD06519 inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and generating DNA single- and double-strand breaks. This leads to cell cycle arrest and tumor cell apoptosis. In addition, ZD06519 is able to induce a bystander effect on neighboring cells in the tumor environment. This inhibits the proliferation of tumor cells. FRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues.",
  "synonyms": [
    "anti-FRa ADC ZW191",
    "anti-FRa/ZD06519 ADC ZW191",
    "anti-FRalpha ADC ZW191"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-fralpha-antibody-drug-conjugate-zw191/"
}