anti-HA epitope monoclonal antibody MEDI8852

{
  "id": "MLC-T-ONC-010726",
  "term": "anti-HA epitope monoclonal antibody MEDI8852",
  "field": "Oncology and biomedicine",
  "definition": "A human immunoglobulin (Ig) G1 kappa monoclonal antibody (mAb) targeting a unique epitope in the stalk of the influenza A hemagglutinin (HA) protein, with broad influenza A virus neutralization activity. MEDI8852 was derived from an antibody isolated from human memory B cells from patients previously infected with influenza caused by type A strains that was further optimized to increase neutralization potential. Upon infusion, MEDI8852 targets and binds to a region within the stalk of the HA protein that is highly conserved amongst all influenza A virus subtypes. This neutralizes and prevents essential steps of the viral lifecycle, thereby blocking infectivity of all influenza A virus subtypes. HA, a glycoprotein found on the surface of the influenza virus, plays a key role in viral attachment and cell entry.",
  "synonyms": [
    "pan-influenza A mAb MEDI8852",
    "anti-influenza A hemagglutinin epitope mAb MEDI8852"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ha-epitope-monoclonal-antibody-medi8852/"
}