anti-HER2 immune stimulator-antibody conjugate NJH395

{
  "id": "MLC-T-ONC-010748",
  "term": "anti-HER2 immune stimulator-antibody conjugate NJH395",
  "field": "Oncology and biomedicine",
  "definition": "An immune stimulator-antibody conjugate (ISAC) composed of a monoclonal antibody targeting human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2) conjugated to a not yet disclosed immune stimulator, with potential antineoplastic and immunostimulating activities. Upon administration of the anti-HER2 immune stimulator-antibody conjugate NJH395, the antibody moiety targets and binds to HER2 expressed on tumor cells. Upon antibody/antigen binding, the immune-stimulating moiety may, through an as of yet undisclosed mechanism, enhance the immune-mediated killing of HER2-expressing tumor cells. HER2, a tyrosine kinase receptor, is overexpressed in many cancer types and plays a key role in tumor cell proliferation and tumor vascularization.",
  "synonyms": [
    "anti-HER2 ISAC NJH395"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-her2-immune-stimulator-antibody-conjugate-njh395/"
}