anti-integrin alphaV/beta8 monoclonal antibody CRB-601

{
  "id": "MLC-T-ONC-010825",
  "term": "anti-integrin alphaV/beta8 monoclonal antibody CRB-601",
  "field": "Oncology and biomedicine",
  "definition": "A humanized immunoglobulin G4 (IgG4) monoclonal antibody directed against integrin alphaV/beta8 (aVb8), with potential antineoplastic activity. Upon administration, anti-integrin aVb8 monoclonal antibody CRB-601 targets and binds to integrin aVb8. This prevents the binding of integrin aVb8 to latent human transforming growth factor (TGF)-beta (L-TGFb) and inhibits the activation of L-TGFb complexes, thereby preventing TGFb-mediated signaling. This abrogates TGFb-mediated immunosuppression, enhances anti-tumor immunity in the tumor microenvironment (TME) and promotes a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells leading to tumor cell death. This may lead to a reduction in TGFb-dependent proliferation of cancer cells. Integrin aVb8 plays a key role in tumor initiation, growth, and progression through TGF-b activation. It is expressed in a variety of tumor cell types and is associated with poor prognosis.",
  "synonyms": [
    "anti-integrin aVb8 monoclonal antibody CRB-601"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-integrin-alphav-beta8-monoclonal-antibody-crb-601/"
}