Anti-integrin Beta-1 Monoclonal Antibody OS2966

{
  "id": "MLC-T-ONC-010826",
  "term": "Anti-integrin Beta-1 Monoclonal Antibody OS2966",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against the human integrin receptor beta-1 subunit (CD29), with potential antineoplastic activity. Upon administration, anti-integrin beta-1 monoclonal antibody OS2966 targets and binds to integrin beta-1 on the surface of tumor cells and macrophages in the tumor microenvironment (TME), thereby preventing integrin beta-1-mediated activation of downstream signaling pathways. This may include the blockade of the binding of integrin beta-1 to the effector kinase focal adhesion kinase (FAK), preventing FAK-mediated activation of Stat1 and Akt. This may inhibit tumor cell proliferation, invasion and migration in integrin beta-1-overexpressing tumor cells. Integrin beta-1, the dominant subunit in all four classes of integrin receptors, plays an important role in tumor cell proliferation, invasion, and drug resistance.",
  "synonyms": [
    "anti-CD29 monoclonal antibody OS2966",
    "anti-integrin beta1 monoclonal antibody OS2966"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-integrin-beta-1-monoclonal-antibody-os2966/"
}