anti-A5B1 integrin monoclonal antibody PF-04605412

{
  "id": "MLC-T-ONC-010112",
  "term": "anti-A5B1 integrin monoclonal antibody PF-04605412",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody directed against the human alpha5beta1 integrin with potential antiangiogenic and antineoplastic activities. Anti-alpha5beta1 integrin monoclonal antibody PF-04605412 selectively binds to alpha5beta1 integrin, preventing the binding of integrin ligands. This may result in the inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, and integrin-mediated tumor angiogenesis and metastasis in alpha5beta1-expressing tumor cells. Alpha5beta1 integrin, a cell adhesion and signaling receptor, is often overexpressed on the surface of tumor vessel endothelial cells and plays a crucial role in endothelial cell adhesion and migration.",
  "synonyms": [
    "anti-alpha5beta1 integrin monoclonal antibody PF-04605412"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-a5b1-integrin-monoclonal-antibody-pf-04605412/"
}