Plasmid encoding antiangiogenic metargidin peptide

{
  "id": "MLC-T-ONC-016106",
  "term": "Plasmid encoding antiangiogenic metargidin peptide",
  "field": "Oncology and biomedicine",
  "definition": "A plasmid encoding the protein antiangiogenic metargidin plasmid (AMEP), the disintegrin domain of ADAM-15 (metargidin), with potential antiangiogenic and antimetastatic activities. Upon intratumoral electrotransfer of plasmid encoding AMEP, AMEP binds to cellular integrin receptors alpha-v-beta-3 (avb3) and alpha-5-beta-1 (a5b1), which are upregulated on activated endothelial cells and a variety of tumor cells. Binding to the integrin receptors may inhibit angiogenesis and may inhibit tumor cell proliferation.",
  "synonyms": [
    "peptide AMEP"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/plasmid-encoding-antiangiogenic-metargidin-peptide/"
}