plasmid DNA vaccine pING-hHER3FL

{
  "id": "MLC-T-ONC-016105",
  "term": "plasmid DNA vaccine pING-hHER3FL",
  "field": "Oncology and biomedicine",
  "definition": "A plasmid DNA cancer vaccine encoding the tumor-associated antigen (TAA) human epidermal growth factor receptor type-3 (HER-3; HER3), with potential antineoplastic and immunomodulating activities. Upon intramuscular administration of the plasmid DNA vaccine pING-hHER3FL and after cellular uptake by muscle cells, the plasmid DNA expresses HER-3 which, may elicit both antigen-specific cytotoxic T-lymphocyte (CTL) and humoral immune responses against tumor cells expressing HER-3. HER-3 plays a key role in tumor cell proliferation and its overexpression is associated with poor prognosis. HER-3 is associated with tumor cell resistance to anti-HER-2 therapeutics.",
  "synonyms": [
    "pING-hHER3FL vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/plasmid-dna-vaccine-ping-hher3fl/"
}