androgen receptor ligand-binding domain-encoding plasmid DNA vaccine MVI-118

{
  "id": "MLC-T-ONC-010079",
  "term": "androgen receptor ligand-binding domain-encoding plasmid DNA vaccine MVI-118",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine containing pTVG4 plasmid DNA encoding the human androgen receptor (AR) ligand-binding domain (LBD) (pTVG-AR), with potential immunostimulating and antineoplastic activities. Upon intradermal administration of AR LBD-encoding plasmid DNA vaccine MVI-118, the plasmid DNA vaccine expresses AR LBD and may stimulate the host immune system to generate a cytotoxic T-lymphocyte (CTL) response against AR LBD-expressing prostate cancer cells. This reduces proliferation of AR-expressing tumor cells. AR, a tumor-associated antigen (TAA) overexpressed in prostate cancer cells, plays a key role in the development and progression of prostate cancer; its expression is correlated with poor prognosis.",
  "synonyms": [
    "pTVG-AR",
    "pTVG-AR vaccine",
    "AR LBD-encoding plasmid DNA vaccine MVI-118"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/androgen-receptor-ligand-binding-domain-encoding-plasmid-dna-vaccine-mvi-118/"
}