alpha V beta 1 inhibitor ATN-161

{
  "id": "MLC-T-ONC-009975",
  "term": "alpha V beta 1 inhibitor ATN-161",
  "field": "Oncology and biomedicine",
  "definition": "A small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN-161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby preventing integrin alpha5beta1 binding. This receptor blockade may result in inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, angiogenesis, and tumor progression. Integrin alpha5beta1 is expressed on endothelial cells and plays a crucial role in endothelial cell adhesion and migration.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/alpha-v-beta-1-inhibitor-atn-161/"
}