anti-PLGF monoclonal antibody TB-403

{
  "id": "MLC-T-ONC-011038",
  "term": "anti-PLGF monoclonal antibody TB-403",
  "field": "Oncology and biomedicine",
  "definition": "A humanized immunoglobulin (Ig) G1 monoclonal antibody directed against the placenta growth factor (PGF), with potential anti-angiogenic and antineoplastic activities. Anti-PGF monoclonal antibody TB-403 binds to both PGF-1 and -2, thereby inhibiting the binding of PGF-1 and -2 to the vascular endothelial growth factor receptor-1 (VEGFR-1) and subsequent VEGFR-1 phosphorylation. This may result in the inhibition of tumor angiogenesis and tumor cell proliferation. PGF, a member of the VEGF sub-family and a key molecule in angiogenesis and vasculogenesis, is upregulated in many cancers.",
  "synonyms": [
    "anti-placental growth factor monoclonal antibody TB-403",
    "anti-PGF monoclonal antibody RO5323441"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-plgf-monoclonal-antibody-tb-403/"
}