anti-plectin monoclonal antibody ZB131

{
  "id": "MLC-T-ONC-011037",
  "term": "anti-plectin monoclonal antibody ZB131",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against human plectin (plectin-1; plectin 1), with potential antineoplastic activity. Upon administration, anti-plectin monoclonal antibody ZB131 specifically binds to plectin expressed on the cell surface of cancer cells, thereby activating the immune system to induce an anti-tumor T-cell response against plectin-expressing cancer cells and inducing apoptosis in these cancer cells. Plectin, a pro-tumorigenic protein, is normally found inside the cytoplasm of healthy cells but is only selectively expressed on the cell surface of various cancer cells. Cancer-specific plectin (CSP), also known as cell surface plectin-1 (CSP1), plays an important role in cancer cell proliferation, migration and invasion.",
  "synonyms": [
    "anti-plectin-1 monoclonal antibody ZB131",
    "anti-CSP monoclonal antibody ZB131",
    "anti-cancer-specific plectin monoclonal antibody ZB131",
    "anti-CSP1 monoclonal antibody ZB131",
    "anti-cell surface plectin 1 monoclonal antibody ZB131",
    "anti-cell surface plectin-1 monoclonal antibody ZB131"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-plectin-monoclonal-antibody-zb131/"
}