anti-STn antibody-drug conjugate SGN-STNV

{
  "id": "MLC-T-ONC-011102",
  "term": "anti-STn antibody-drug conjugate SGN-STNV",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of an antibody directed against the tumor-associated carbohydrate antigen Sialyl Thomsen-nouveau (STn) conjugated to the cytotoxic agent monomethyl auristatin E (MMAE) via the MC-vc-PAB linker, with potential antineoplastic activity. Upon administration of the anti-STn ADC SGN-STNV, the anti-STn antibody targets and binds to STn expressed on tumor cells. Following internalization of SGN-STNV and release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in STn-expressing tumor cells. STn, a tumor-associated carbohydrate antigen that is present on various tumor-associated glycoproteins including CA-125 and mucin-1 (MUC1), is expressed in multiple tumor types.",
  "synonyms": [
    "anti-STn vedotin ADC SGN-STNV",
    "anti-Sialyl Thomsen-nouveau antibody-drug conjugate SGN-STNV",
    "anti-STn ADC SGN-STNV",
    "ADC SGN-STNV"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-stn-antibody-drug-conjugate-sgn-stnv/"
}