anti-STEAP1 CAR T cells

{
  "id": "MLC-T-ONC-011101",
  "term": "anti-STEAP1 CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) six transmembrane epithelial antigen of the prostate 1 (STEAP1), with potential immunostimulating and antineoplastic activities. Upon administration, anti-STEAP1 CAR T cells recognize and bind to STEAP1-expressing tumor cells, thereby inducing selective toxicity in STEAP1-expressing tumor cells. STEAP1 is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "anti-STEAP1 CAR-T cells",
    "STEAP1 CAR-T cells",
    "STEAP1-targeting CAR T cells",
    "STEAP1-targeting CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-steap1-car-t-cells/"
}