anti-tissue factor monoclonal antibody MORAb-066

{
  "id": "MLC-T-ONC-011138",
  "term": "anti-tissue factor monoclonal antibody MORAb-066",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody against human tissue factor (TF), with potential antiangiogenic, anticoagulant and anti-inflammatory activities. Upon administration, anti-TF monoclonal antibody MORAb-066 binds to TF and prevents Factor VIIa (FVIIa) from binding, thereby interfering with the activation of Factor X (FX) into FXa. This may prevent thrombin formation and cancer-associated venous thromboembolism, and may inhibit angiogenesis and tumor cell proliferation. TF, a transmembrane protein and initiator of the coagulation cascade, is overexpressed in many tumor cells and tumor endothelial cells; its expression is correlated with metastasis, angiogenesis, tumor cell growth and tumor-associated thrombosis.",
  "synonyms": [
    "anti-TF monoclonal antibody MORAb-066"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-tissue-factor-monoclonal-antibody-morab-066/"
}