anti-endosialin/TEM1 monoclonal antibody MORAb-004

{
  "id": "MLC-T-ONC-010626",
  "term": "anti-endosialin/TEM1 monoclonal antibody MORAb-004",
  "field": "Oncology and biomedicine",
  "definition": "A humanized IgG1 monoclonal antibody directed against human endosialin/TEM1 (tumor endothelial marker;CD248) with potential anti-angiogenic and antineoplastic activities. Anti-endosialin/TEM1 monoclonal antibody MORAb-004 binds to and inhibits the activity of cell surface protein endosialin/TEM1, which may result in the inhibition of angiogenesis, tumor cell proliferation and metastasis. Endosialin/TEM1 plays a key role in angiogenesis and may be overexpressed on tumor stromal cells and endothelial cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-endosialin-tem1-monoclonal-antibody-morab-004/"
}